Just spit ballin here, but I think flat sides are supposed to flow faster with the same size. I vaguely recall something about the different venturis created by the shape of the slide. This also would effect the power curve. And this would also assume your cam timing is setup to deal with the air, but I think we are ignoring this part based on your stipulations.
I don't know of a single Keihin that would work on VFR, maybe something for a HD? You'd have to make a custom manifold, but that is not terribly hard. I don't know what if any the advantages would be of the single carb set up. It would make jetting for elevation change easier, although less precise.