Hi Ascalon,
I am running F2 wheels on my VF750F, and had Pirelli Rosso (something or others), Dunlop RoadSmrts on the rear, and now recently put on Michelin PilotRoad3s. All were 120/70-17 and 160/60-17. I often rode with full touring set-up (cases, topbox, campinggear).
I really like how the PR3s feel. But recall the RoadSmart was a good dual compound rear. Pirellis were on before all the suspension tweaks.
Things to consider are over all rear height. I believe the stock rear wheel on VF1000 is 17" so maybe not much change other than a bit of tire sidewall stiffness and relative height. The front overall circumference was pretty close between the old and new so that was ok.
I had to adjust suspension a lot and now the new Michelin tires really feel great, and am very confident on the ol'VF. Hope you find the same with your set up.