I would first start with supplments. Why, because it works for me. Daily, I take Cissus root (made by USP labs) and fish oils. They work great! I want to start with glucosomine but I'm allergic to shrimp so I have to wait until I "test" out that theory. I can say my friend take all the above and it has really helped out his wrists.
For the bike, I have heli's, grip puppies on my 5th gen. It really helps along with a light grip on the bars. Of course, squeeze more with the legs and strengthing the core helps too. Good luck!